Ceftiofur is widely used in veterinary medicine for the treatment of bacterial infections in livestock and poultry. It is effective against a range of Gram-negative and Gram-positive bacteria, making it a common choice for managing respiratory infections in cattle, such as bovine respiratory disease (BRD). It is also used to treat infections in swine, including pneumonia and septicemia, and in poultry for conditions like E. coli infections. The drug is administered via injection and is valued for its rapid absorption and conversion to active metabolites that provide sustained antibacterial activity. Due to its broad-spectrum efficacy and short withdrawal times in some species, ceftiofur is often used in food-producing animals. However, its use is closely monitored to prevent the development of antibiotic resistance, especially in pathogens that may affect human health.