Used primarily in the treatment and prevention of malaria, particularly in regions where resistance to other antimalarial drugs like chloroquine has developed. It is effective against Plasmodium falciparum, the most dangerous malaria parasite. Amodiaquine is often combined with other antimalarial agents, such as artesunate, in artemisinin-based combination therapies (ACTs), which are recommended by the World Health Organization for uncomplicated malaria. Its use is limited in some areas due to concerns about liver toxicity and low blood cell counts with prolonged use, but it remains an important option in short-term treatment and in specific patient groups under medical supervision.