6α-Naloxol is primarily used in research and development within the field of pharmacology, particularly in studies related to opioid receptors. It serves as a reference standard or analytical tool for the development and validation of analytical methods, such as chromatography or mass spectrometry, to detect and quantify opioid compounds. Researchers utilize it to better understand the metabolism, pharmacokinetics, and pharmacodynamics of opioid antagonists and their derivatives. Additionally, it plays a role in exploring the structural and functional relationships of opioid receptor ligands, aiding in the design of new therapeutic agents targeting opioid-related disorders. Its application is critical in advancing the development of drugs for pain management, addiction treatment, and overdose reversal.