Used as a key intermediate in the synthesis of third-generation cephalosporin antibiotics, particularly in the production of ceftriaxone and cefotaxime. Its structure enables effective beta-lactam ring formation, enhancing antibacterial activity against a broad spectrum of Gram-positive and Gram-negative bacteria. The (E)-isomer is especially important for optimal biological activity. Widely utilized in pharmaceutical manufacturing due to its reactivity and stability in coupling reactions.