Dihydroergotamine Mesylate is primarily used in the treatment of migraine headaches, particularly for acute cases where rapid relief is necessary. It is effective in reducing the severity of migraines, including symptoms like nausea, vomiting, and sensitivity to light or sound. The compound works by constricting blood vessels around the brain, which helps alleviate the pain associated with migraines. It is often administered via injection or nasal spray for faster absorption and quicker results. Additionally, it is sometimes used to manage cluster headaches, though less commonly. Due to its potent effects, it is typically reserved for patients who do not respond well to other migraine treatments. Proper dosing and medical supervision are essential to minimize potential side effects, such as nausea, dizziness, or more severe cardiovascular complications.