Used in hormone replacement therapy to relieve symptoms of menopause such as hot flashes, night sweats, vaginal dryness, and mood changes. It helps restore estrogen levels in women whose ovaries no longer produce sufficient amounts. Often combined with progestin in women with an intact uterus to reduce the risk of endometrial cancer. Also prescribed to prevent osteoporosis in postmenopausal women at high risk of fractures. May be used in certain cases to treat breast cancer in women and men, though this is less common. Administered orally, it provides a sustained release of estrogen due to its conjugated structure, allowing for lower dosing frequency.