10-Deacetylbaccatin III (10-DAB)
10mM in DMSO
Reagent
Code: #168897
CAS Number
32981-86-5
science Other reagents with same CAS 32981-86-5
blur_circular Chemical Specifications
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Molecular Information
Weight
544.59 g/mol
Formula
C₂₉H₃₆O₁₀
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Registry Numbers
MDL Number
MFCD00132913
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Storage & Handling
Storage
-20°C
description Product Description
Used primarily as a key starting material in the semi-synthesis of anticancer drugs, especially paclitaxel (Taxol) and docetaxel (Taxotere). These drugs stabilize microtubules, inhibiting cell division and inducing apoptosis in cancer cells. 10-DAB is preferred over direct extraction of paclitaxel due to higher availability from renewable sources like yew tree needles. It allows for scalable, cost-effective production of taxane-based chemotherapeutics used in treating breast, ovarian, lung, and other cancers. Its structural complexity makes it ideal for targeted chemical modifications to develop new derivatives with improved solubility, efficacy, or reduced resistance.
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