Artemether is widely used in the treatment of malaria, particularly for severe and multidrug-resistant cases. It is a key component of artemisinin-based combination therapies (ACTs), which are the first-line treatment recommended by the World Health Organization (WHO) for uncomplicated Plasmodium falciparum malaria. The compound works by rapidly reducing the number of malaria parasites in the bloodstream, alleviating symptoms and preventing complications. It is often administered via intramuscular injection for severe malaria, ensuring quick absorption and action. Artemether is also effective in treating cerebral malaria, a life-threatening complication. Its use has significantly contributed to reducing malaria-related mortality, especially in endemic regions. However, it is typically used in combination with other antimalarial drugs to prevent the development of resistance.