Tolfenpyrad is primarily used as an insecticide in agricultural settings. It effectively controls a wide range of pests, particularly in crops such as fruits, vegetables, and ornamental plants. Its mode of action involves inhibiting mitochondrial respiration in insects, leading to rapid cessation of feeding and eventual death. Due to its systemic properties, tolfenpyrad is absorbed and distributed within plant tissues, offering both contact and translaminar protection. It is especially effective against sucking and chewing pests like aphids, thrips, and mites. The solution in acetonitrile is often used in analytical applications or as a reference standard in quality control and residue testing, ensuring accurate measurement of tolfenpyrad levels in environmental and agricultural samples.