Terbuthylazine is primarily used as a selective herbicide in agriculture, especially in corn (maize) and sorghum crops. It controls a broad spectrum of annual grasses and broadleaf weeds by inhibiting photosynthesis in susceptible plants. The solution formulation allows for easy mixing and application through standard spray equipment, making it suitable for pre- and post-emergence weed control. It is particularly effective in regions with heavy weed pressure and is often used in integrated weed management programs. Due to its residual activity in soil, it provides extended control, reducing the need for frequent reapplication. Terbuthylazine is also used in combination with other herbicides to broaden the spectrum of weed control and to help manage herbicide-resistant weed populations. Care must be taken to avoid runoff into water bodies, as it can persist in the environment and has potential effects on non-target vegetation and aquatic systems. Its use is regulated in many countries to ensure environmental safety while maintaining effective crop protection.