Sulcotrione is primarily used as a selective herbicide in agriculture, especially in corn (maize) crops. It controls a broad spectrum of broadleaf weeds and some grassy weeds by inhibiting the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD), which is essential for photosynthetic pigment synthesis in plants. This inhibition leads to bleaching of foliage and eventual weed death, while the crop remains unaffected due to selective metabolism.

It is particularly effective when applied early in the growing season, either pre-emergence or early post-emergence of weeds. Sulcotrione allows for flexible application timing and is often used in integrated weed management programs to reduce reliance on multiple herbicide modes of action. Due to its favorable environmental profile and low persistence in soil, it is considered suitable for use in rotation systems. Its use contributes to improved crop yields by minimizing competition from weeds without harming the maize plants.