Oxyfluorofen is a widely used herbicide in agricultural and non-cultivated areas for the control of broadleaf weeds and certain grasses. It is particularly effective in pre-emergence and early post-emergence applications in crops such as soybeans, cotton, corn, and vegetables. The chemical works by inhibiting protoporphyrinogen oxidase (PPO), an enzyme critical in chlorophyll synthesis, leading to the accumulation of toxic compounds in plant cells and rapid desiccation under sunlight. It is commonly applied in orchards, vineyards, and plantation crops due to its residual activity and soil stability. Oxyfluorofen is also used in non-agricultural settings like industrial sites, roadsides, and fence lines for long-term weed management. Because of its low water solubility and strong soil binding, it poses a lower risk of leaching, making it suitable for use in areas with environmental sensitivity. It is often part of integrated weed management programs to combat herbicide-resistant weed species.