Oxyfluorofen is widely used as a pre-emergent and post-emergent herbicide in agriculture and non-crop areas. It effectively controls annual broadleaf weeds and some grassy weeds in orchards, vineyards, field crops, and ornamental plants. The chemical works by inhibiting protoporphyrinogen oxidase (PPO), an enzyme essential for chlorophyll synthesis, leading to the accumulation of toxic compounds in plant cells and rapid desiccation under sunlight. It is commonly applied to soil before weed seeds germinate, forming a chemical barrier that prevents weed establishment. Due to its residual activity, it provides long-lasting weed control with a single application. Oxyfluorofen is especially useful in crops like soybeans, cotton, and tree nuts where selective weed control is critical. In non-agricultural settings, it is used for vegetation management in industrial sites, roadsides, and around storage facilities. It is often favored for its low volatility and minimal leaching potential, reducing the risk of off-target movement. However, care must be taken during application to avoid contact with desirable plants, as it can cause severe phytotoxicity.