Oxyfluorofen is widely used as a pre-emergence and early post-emergence herbicide in agriculture and non-crop areas. It effectively controls annual broadleaf and grassy weeds in crops such as soybeans, cotton, corn, and orchards. It is also applied in vineyards and ornamental plantings. The chemical works by inhibiting protoporphyrinogen oxidase (PPO), leading to the accumulation of toxic compounds in plant cells that cause rapid desiccation and tissue destruction upon light exposure. Due to its residual activity in soil, it provides extended weed control, reducing the need for frequent applications. It is often used in integrated weed management programs, especially where resistance to other herbicides is a concern. Oxyfluorofen is also utilized in aquatic and industrial settings for vegetation control along ditches, roadsides, and irrigation systems. Its low water solubility and strong soil binding reduce leaching risk, making it suitable for use in various environmental conditions.