Oxyfluorofen is widely used as a pre-emergence and early post-emergence herbicide in agriculture and non-crop areas. It effectively controls annual broadleaf and grassy weeds in a variety of settings, including orchards, vineyards, soybean fields, and ornamental crops. The chemical works by inhibiting protoporphyrinogen oxidase (PPO), an enzyme critical in chlorophyll synthesis, leading to the accumulation of toxic compounds in plant cells and rapid desiccation under light. It is especially valued for residual weed control, providing protection for several weeks after application. Oxyfluorofen is commonly applied as a directed spray or soil treatment to minimize weed competition during crop establishment. Due to its soil-binding properties and low leaching potential, it is considered suitable for use in areas with environmental sensitivity when applied according to label guidelines. It is also used in aquatic and industrial settings for managing invasive vegetation.