Oxyfluorofen is widely used as a pre-emergent and post-emergent herbicide in agriculture and non-crop areas. It effectively controls annual broadleaf and grassy weeds in crops such as soybeans, cotton, corn, and orchards. It is also applied in vineyards, ornamental plants, and tree nurseries. The chemical works by inhibiting protoporphyrinogen oxidase (PPO), an enzyme essential for chlorophyll synthesis. This disruption leads to the accumulation of toxic compounds in plant cells, causing rapid cell membrane damage and plant death upon exposure to light. Due to its residual activity in soil, oxyfluorofen provides long-lasting weed control, reducing the need for frequent reapplication. It is often used in integrated weed management programs, especially where resistance to other herbicides has developed. Oxyfluorofen is also utilized in aquatic environments and industrial settings for controlling unwanted vegetation along ditches, roadsides, and irrigation systems. Its low water solubility and strong soil adsorption minimize leaching, making it suitable for use in areas with environmental sensitivity when applied according to guidelines.