Monolinuron is primarily used as a selective herbicide in agriculture. It controls broadleaf weeds and grasses in crops such as potatoes, sugar beets, and vegetables. Applied pre-emergence, it prevents weed seed germination by inhibiting photosynthesis in susceptible plants. Its effectiveness in low doses makes it suitable for integrated weed management programs. Monolinuron remains active in the top layer of soil, providing residual control for several weeks. Due to its persistence and potential environmental impact, it is used under regulated conditions to minimize leaching into groundwater.