Used as a reference standard in analytical laboratories for the quantification and detection of imidazole compounds in pharmaceuticals, biological samples, and industrial products. Commonly employed in HPLC and GC methods to ensure accurate calibration and system suitability testing. Helps maintain quality control in the production of drugs containing imidazole rings, such as antifungals and histamine analogs. Also utilized in research settings to study enzyme inhibition and buffer systems where imidazole is a functional component.