Fentrazamide is primarily used as a selective herbicide in agriculture, especially in the cultivation of rice. It effectively controls annual grasses and broadleaf weeds by inhibiting cell division in root and shoot meristems of susceptible plants. The compound is applied pre-emergence, meaning it is used before weeds break the soil surface, allowing it to form a chemical barrier in the top layer of soil. Due to its selectivity, fentrazamide shows minimal phytotoxicity to rice when used at recommended rates, making it suitable for use in both transplanted and direct-seeded rice systems. Its persistence in soil is moderate, providing extended weed control without causing long-term residual effects that could impact crop rotation. Fentrazamide is often included in integrated weed management programs to reduce reliance on multiple post-emergence herbicides and to manage herbicide-resistant weed populations.