Flupyradifurone is a systemic insecticide used primarily to control sap-feeding insects such as aphids, whiteflies, planthoppers, and leafhoppers in a wide range of crops including fruits, vegetables, cotton, and ornamentals. It is particularly effective in agricultural settings where resistance to other insecticide classes has developed. Due to its unique mode of action—acting on the insect’s nicotinic acetylcholine receptors without cross-resistance to neonicotinoids—it is often used in resistance management programs. The compound is applied through soil drenching, seed treatment, or foliar spray, allowing flexible use depending on crop and pest pressure. It shows rapid uptake and distribution within the plant, providing quick knockdown and long-lasting protection. Flupyradifurone is also considered to have a favorable environmental profile, with lower risk to beneficial insects like bees when used according to label directions.