Cloquintocet-mexyl is primarily used as a safener in agricultural herbicides to protect crops from herbicide damage. It is often combined with herbicides like fenoxaprop-P-ethyl to enhance their selectivity, ensuring that the herbicide targets weeds without harming the desired crops, particularly cereals such as wheat and barley. By mitigating the phytotoxic effects of herbicides, it allows for more effective weed control while maintaining crop health and yield. This application is especially valuable in integrated weed management systems, where minimizing crop damage is critical for sustainable agriculture.