GSK0660 is primarily utilized in research settings as a potent and selective antagonist of the peroxisome proliferator-activated receptor delta (PPARδ). It is extensively used in biochemical and pharmacological studies to investigate the role of PPARδ in various biological processes. Researchers employ GSK0660 to explore its effects on metabolic regulation, particularly in relation to lipid metabolism, glucose homeostasis, and energy expenditure. Additionally, it is used to study the receptor's involvement in inflammation, neurodegenerative diseases, and cancer. By inhibiting PPARδ, GSK0660 helps elucidate the receptor's signaling pathways and its potential as a therapeutic target. Its application is crucial in preclinical studies aimed at understanding disease mechanisms and developing targeted therapies.