Perfluoro-tert-butanol is primarily used as a versatile intermediate in organic synthesis, particularly in the preparation of fluorinated compounds. Its strong electron-withdrawing properties make it valuable in the development of specialty chemicals, including pharmaceuticals and agrochemicals, where it can enhance stability and reactivity. Additionally, it is employed in the production of advanced materials, such as fluoropolymers, which are used in high-performance coatings and membranes due to their resistance to heat, chemicals, and solvents. In research, it serves as a reagent for studying reaction mechanisms and as a building block for creating complex molecular structures. Its unique properties also make it useful in analytical chemistry as a derivatization agent for improving detection sensitivity in gas chromatography and mass spectrometry.