1-Boc-D-prolyl-glycine is a Boc-protected dipeptide (N-Boc-D-Pro-Gly-OH) used as a building block in peptide synthesis, particularly for incorporating D-proline-glycine units into complex peptides and peptidomimetics. The tert-butoxycarbonyl (Boc) group protects the N-terminal amine, enabling selective deprotection and coupling reactions during chain assembly without interfering with other functional groups.

It is widely applied in pharmaceutical and medicinal chemistry research for developing drug candidates, such as protease inhibitors, antimicrobial agents, and other bioactive peptides. The stability of the Boc group under basic conditions and its facile removal under acidic conditions make it a versatile tool in both solid-phase and solution-phase synthesis strategies.

This specialty chemical intermediate is essential for precise control in organic synthesis and is not suitable for general commodity applications.