(2S,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-phenylpyrrolidine-2-carboxylic acid
≥95%
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description Product Description
This compound, (2S,4R)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-phenylpyrrolidine-2-carboxylic acid, is an Fmoc-protected derivative of trans-4-phenylproline. It serves as a specialized building block in solid-phase peptide synthesis (SPPS), where the fluorenylmethoxycarbonyl (Fmoc) group protects the pyrrolidine nitrogen, preventing side reactions during stepwise peptide assembly on a resin. The Fmoc protection is orthogonally removable under mild basic conditions (e.g., piperidine), preserving the integrity of the growing peptide chain. The chiral (2S,4R) configuration and 4-phenyl substitution enable the synthesis of stereospecific peptides with modified properties, essential for pharmaceutical research, drug development, and studies of protein folding or enzyme inhibition.
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