Used as a reagent in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), where it serves to deprotect amino acid side chains and terminal protecting groups. Its volatility allows for easy removal after reaction, minimizing residual contamination in the final product. Commonly employed in the cleavage of synthetic peptides from resin supports and in the removal of acid-labile protecting groups. Preferred in automated synthesizers due to its efficiency and compatibility with sensitive amino acids. Also utilized in the preparation of pharmaceutical intermediates and in research settings for synthesizing bioactive peptides.