Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP
Reagent
Code: #133306
CAS Number
253863-34-2
science Other reagents with same CAS 253863-34-2
blur_circular Chemical Specifications
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Molecular Information
Weight
802.83 g/mol
Formula
C₄₀H₄₆N₆O₁₂
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Registry Numbers
MDL Number
MFCD22200436
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Physical Properties
Boiling Point
1059.2±65.0 °C(Predicted)
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Storage & Handling
Density
1.285±0.06 g/cm3(Predicted)
Storage
-20°C
description Product Description
Used in solid-phase peptide synthesis as a protected tripeptide building block, particularly in the preparation of antibody-drug conjugates (ADCs). The Aloc (allyloxycarbonyl) groups serve as orthogonal protecting groups that can be selectively removed under mild conditions, allowing stepwise peptide assembly. The PAB (para-aminobenzyl) linker acts as a spacer and is commonly employed as a self-immolative linker in prodrug and ADC design. Upon enzymatic cleavage, the PAB-PNP moiety releases active payloads, making this compound valuable in the development of targeted therapeutics, especially in cancer drug delivery systems where controlled release is critical.
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