Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP

Reagent Code: #133306
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CAS Number 253863-34-2

science Other reagents with same CAS 253863-34-2

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 802.83 g/mol
Formula C₄₀H₄₆N₆O₁₂
badge Registry Numbers
MDL Number MFCD22200436
thermostat Physical Properties
Boiling Point 1059.2±65.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.285±0.06 g/cm3(Predicted)
Storage -20°C

description Product Description

Used in solid-phase peptide synthesis as a protected tripeptide building block, particularly in the preparation of antibody-drug conjugates (ADCs). The Aloc (allyloxycarbonyl) groups serve as orthogonal protecting groups that can be selectively removed under mild conditions, allowing stepwise peptide assembly. The PAB (para-aminobenzyl) linker acts as a spacer and is commonly employed as a self-immolative linker in prodrug and ADC design. Upon enzymatic cleavage, the PAB-PNP moiety releases active payloads, making this compound valuable in the development of targeted therapeutics, especially in cancer drug delivery systems where controlled release is critical.

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Size Availability Unit Price Quantity
inventory 25mg
10-20 days ฿47,500.00

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Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP
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Used in solid-phase peptide synthesis as a protected tripeptide building block, particularly in the preparation of antibody-drug conjugates (ADCs). The Aloc (allyloxycarbonyl) groups serve as orthogonal protecting groups that can be selectively removed under mild conditions, allowing stepwise peptide assembly. The PAB (para-aminobenzyl) linker acts as a spacer and is commonly employed as a self-immolative linker in prodrug and ADC design. Upon enzymatic cleavage, the PAB-PNP moiety releases active payloads, making this compound valuable in the development of targeted therapeutics, especially in cancer drug delivery systems where controlled release is critical.
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