AZD2461
10mM in DMSO
Reagent
Code: #134114
CAS Number
1174043-16-3
blur_circular Chemical Specifications
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Molecular Information
Weight
395.43 g/mol
Formula
C₂₂H₂₂FN₃O₃
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Registry Numbers
MDL Number
MFCD24386811
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Storage & Handling
Storage
-20°C
description Product Description
Used in oncology research as a potent inhibitor of poly(ADP-ribose) polymerase (PARP), particularly targeting tumors with defects in DNA repair pathways. Shows potential in overcoming resistance to earlier PARP inhibitors, making it valuable in studies involving BRCA-mutated and other homologous recombination-deficient cancers. Investigated for its ability to enhance the effects of DNA-damaging agents like chemotherapy and radiation in preclinical models. Currently limited to experimental use and not approved for clinical treatment.
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