The PEPPSI!-IPr catalyst is widely used in organic synthesis, particularly in cross-coupling reactions such as the Suzuki-Miyaura, Negishi, and Buchwald-Hartwig reactions. Its effectiveness in facilitating carbon-carbon and carbon-heteroatom bond formation makes it a valuable tool in pharmaceutical development, enabling the synthesis of complex drug molecules. Additionally, it is employed in materials science for creating advanced polymers and functional materials. The catalyst’s stability and versatility under various reaction conditions enhance its utility in both academic research and industrial applications.