Widely used in cross-coupling reactions, especially in pharmaceutical synthesis where high catalytic efficiency and mild reaction conditions are required. It enables C–C bond formation such as Suzuki–Miyaura and Buchwald–Hartwig aminations, making it valuable for constructing complex organic molecules. Its stability and solubility in common organic solvents simplify handling and improve reproducibility in both lab-scale and industrial processes. Particularly effective for coupling aryl chlorides, which are less reactive and more cost-effective than bromides or iodides. The methyl t-butyl ether adduct form enhances catalyst shelf life and ease of use without requiring inert atmosphere handling in many cases.