Widely used as a highly active catalyst in cross-coupling reactions, particularly in Suzuki-Miyaura coupling, enabling the formation of carbon-carbon bonds between aryl halides and arylboronic acids. Its bulky phosphine ligand enhances catalyst stability and promotes efficient turnover, even with sterically hindered substrates. It is especially effective in the synthesis of biaryl compounds, which are key structural motifs in pharmaceuticals, agrochemicals, and organic materials. The presence of the amino group on the biphenyl moiety can facilitate ligand coordination and improve catalytic performance under mild reaction conditions. Commonly employed in late-stage functionalization due to its functional group tolerance and high selectivity.