Widely used as a palladium-based catalyst in cross-coupling reactions, particularly in Suzuki-Miyaura and Buchwald-Hartwig aminations. Its bulky di-tert-butylphenylphosphine ligands enhance catalytic activity and stability, allowing efficient coupling of aryl chlorides, which are less reactive and more cost-effective than bromides or iodides. This makes the complex valuable in pharmaceutical and agrochemical synthesis where complex aromatic systems are common. It enables reactions under milder conditions and often provides high yields with good functional group tolerance.