Used as a highly active catalyst in cross-coupling reactions, particularly in Buchwald–Hartwig amination and Suzuki–Miyaura coupling. It enables efficient carbon–nitrogen and carbon–carbon bond formation under mild conditions, making it valuable in pharmaceutical synthesis and the development of complex organic molecules. Its bulky phosphine ligand enhances stability and reactivity, especially with sterically hindered substrates. Commonly employed in late-stage functionalization of drug candidates and in the preparation of functional materials.