Widely used as a highly active catalyst in cross-coupling reactions, especially in Buchwald–Hartwig amination and Suzuki–Miyaura coupling. Its robust structure enhances stability and promotes efficient carbon–nitrogen and carbon–carbon bond formation, making it valuable in pharmaceutical synthesis and fine chemical manufacturing. The presence of the acetanilide ligand improves selectivity and reactivity under mild conditions, allowing for excellent yields with low catalyst loading. Commonly applied in the preparation of complex organic molecules, including drug intermediates and functional materials.