Widely used as a highly efficient catalyst in cross-coupling reactions, particularly in Buchwald–Hartwig amination, enabling the formation of carbon–nitrogen bonds between aryl halides and amines. Its bulky phosphine ligands enhance reactivity and selectivity, especially with sterically hindered or electron-deficient substrates. Commonly applied in the synthesis of pharmaceuticals, agrochemicals, and functional materials where precise amination is critical. Exhibits good stability and turnover, making it suitable for low-catalyst-loading reactions, reducing metal contamination in final products. Also effective in Suzuki–Miyaura and other palladium-catalyzed transformations under mild conditions.