Widely used as a highly active catalyst in cross-coupling reactions, particularly in Suzuki-Miyaura and Buchwald-Hartwig aminations. Its sterically bulky phosphine ligands enhance reactivity and stability, enabling efficient carbon-carbon and carbon-nitrogen bond formation under mild conditions. Commonly applied in pharmaceutical synthesis and fine chemical manufacturing where high selectivity and turnover are required. Also effective in catalyzing coupling reactions involving aryl chlorides, which are less reactive and more cost-effective substrates compared to bromides or iodides. The air-stable nature of the complex simplifies handling and storage in industrial settings.