PACAP 6-38 is primarily used in research settings to study the role of PACAP (pituitary adenylate cyclase-activating polypeptide) in various physiological processes. It acts as a PAC1 receptor antagonist, effectively blocking the action of PACAP, which helps researchers understand its involvement in neurotransmission, neuroprotection, and inflammation. This peptide is particularly valuable in neuroscience studies, where it is used to investigate PACAP's effects on pain perception, stress responses, and circadian rhythms. Additionally, PACAP 6-38 is utilized in studies exploring its potential role in conditions like migraines, psychiatric disorders, and neurodegenerative diseases, providing insights into therapeutic targets and mechanisms.