2-Butanone oxime is primarily used as an anti-skinning agent in the paint and coatings industry, preventing the formation of a surface film during storage and application. It also functions as an oxidation inhibitor and stabilizer in the polymer industry, protecting materials from degradation during the production of plastics and resins. Additionally, it serves as an intermediate in the synthesis of various organic compounds, including corrosion inhibitors for cooling systems and lubricants, as well as a blocking agent for isocyanates in polyurethane manufacturing. Its versatile properties make it essential in these niche chemical applications.