Potassium cyclobutyltrifluoroborate is primarily used in organic synthesis as a versatile reagent, particularly in cross-coupling reactions. It serves as a stable and efficient source of the cyclobutyl group, enabling the introduction of this moiety into complex molecules. This compound is especially valuable in Suzuki-Miyaura coupling reactions, where it facilitates the formation of carbon-carbon bonds between cyclobutyl groups and aryl or vinyl halides. Its stability and ease of handling make it a preferred choice for constructing cyclobutyl-containing compounds, which are of interest in pharmaceutical and material science research. Additionally, it is employed in the development of novel organic frameworks and bioactive molecules, contributing to advancements in drug discovery and chemical innovation.