Ethyl(trimethyl)silane is an organosilicon compound primarily used as a reference standard in nuclear magnetic resonance (NMR) spectroscopy, especially for ²⁹Si NMR, due to its characteristic chemical shift. It also serves as an internal standard in gas chromatography (GC) for calibration purposes. In organic synthesis, it acts as a building block for more complex silicon-containing molecules, often via transition-metal-catalyzed cross-coupling reactions or C-H activation methods. Additionally, it is employed in materials science for surface modification of substrates to introduce hydrophobic characteristics, and in the study of silicon-carbon bond properties.