Bis(di-tert-butylphosphino)methane is widely used as a ligand in organometallic chemistry, particularly in the synthesis of transition metal complexes. Its bulky tert-butyl groups provide steric protection, making it valuable in stabilizing low-coordinate metal centers and facilitating catalytic processes. It is often employed in homogeneous catalysis, including hydrogenation, hydroformylation, and cross-coupling reactions, where it enhances selectivity and efficiency. Additionally, its strong electron-donating properties make it useful in the development of highly reactive metal catalysts for organic transformations. This ligand is also explored in the study of fundamental coordination chemistry and the design of novel catalytic systems.