sec-Butyllithium solution is widely used as a strong base and nucleophile in organic synthesis. It is commonly employed in the polymerization of styrene, butadiene, and isoprene to produce synthetic rubbers and plastics. In addition, it serves as an initiator for anionic polymerization reactions, enabling the production of well-defined polymers with controlled molecular weights.

This chemical is also utilized in the deprotonation of weakly acidic compounds, facilitating the formation of carbanions for further reactions. It plays a critical role in the synthesis of complex organic molecules, including pharmaceuticals and fine chemicals, by enabling the formation of carbon-carbon bonds.

In research and development, sec-butyllithium is often used to prepare organolithium reagents, which are essential intermediates in various organic transformations. Its high reactivity makes it a valuable tool in the development of new materials and chemical processes. Proper handling is required due to its pyrophoric nature and sensitivity to air and moisture.