Sodium tetrakis(perfluorophenyl)borate is widely used as a co-catalyst in polymerization reactions, particularly in the production of polyolefins. It enhances the activity of metallocene catalysts, improving the efficiency and control of the polymerization process.

This compound is also employed in organic synthesis as a non-coordinating anion, facilitating reactions that require weakly coordinating counterions. It is especially useful in stabilizing cationic intermediates in various chemical transformations.

In electrochemistry, it serves as an electrolyte additive in lithium-ion batteries, improving conductivity and battery performance. Its ability to stabilize highly reactive species makes it valuable in advanced energy storage systems.

Additionally, it finds application in the development of ionic liquids, where it contributes to creating solvents with unique properties for specialized chemical processes. Its thermal and chemical stability makes it suitable for high-performance applications in demanding environments.