Sampsone B is primarily used in organic synthesis as an intermediate in the preparation of complex natural products and pharmaceuticals. It exhibits utility in cross-coupling reactions, where it facilitates the formation of carbon-carbon bonds under mild conditions. Its structural features make it suitable for use in catalytic cycles, particularly in palladium-mediated transformations. Additionally, Sampsone B has been employed in research settings to develop new methodologies for asymmetric synthesis, contributing to the advancement of enantioselective reaction techniques. Its reactivity profile allows for selective functionalization, making it valuable in the design of bioactive molecules and medicinal chemistry campaigns.