Used as a key building block in medicinal chemistry, particularly in the development of novel pharmaceuticals. Its unique rigid structure helps improve metabolic stability and binding selectivity in drug candidates. Commonly employed in bioisosteric replacements for phenyl or alkynyl groups, it enhances pharmacokinetic properties. Widely applied in radiolabeling and PET imaging due to the presence of iodine, enabling diagnostic applications. Also utilized in fragment-based drug discovery for creating three-dimensional molecular architectures.