KIA is widely used in organic synthesis as a strong base and nucleophile. It facilitates deprotonation of weakly acidic compounds and is particularly effective in promoting elimination and substitution reactions. Its reactivity makes it valuable in the preparation of alkenes from alkyl halides and in the generation of enolate ions for carbon-carbon bond formation. Due to its high basicity, it is also employed in the synthesis of pharmaceuticals and fine chemicals where precise control over reaction conditions is required. Handling requires care due to its moisture sensitivity and potential for exothermic reactions with protic substances.