DAMGO is widely used in neuroscience research to study the mu-opioid receptor, one of the key receptors involved in pain modulation, reward, and addictive behaviors. It acts as a selective agonist, making it a valuable tool for understanding opioid signaling pathways in the central nervous system. Researchers use DAMGO in in vitro and in vivo experiments to investigate pain mechanisms, respiratory depression, and the development of tolerance to opioids. It is also employed in receptor binding assays and functional studies to evaluate the efficacy and potency of new opioid-related drugs. Due to its high selectivity, DAMGO helps isolate mu-receptor effects from those of delta or kappa opioid receptors, providing clearer insights into targeted therapeutic interventions.