Naloxegol oxalate is primarily used in the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. It works by blocking the effects of opioids on the gut, thereby helping to restore normal bowel movements without interfering with the pain-relieving effects of opioids. This makes it particularly useful for patients who require long-term opioid therapy for pain management but struggle with constipation as a side effect. It is typically administered orally and is often prescribed when traditional laxatives have not been effective. Its targeted action in the gastrointestinal tract helps improve the quality of life for patients by alleviating a common and distressing side effect of opioid use.