Difluprednate is primarily used in ophthalmology as a potent corticosteroid to treat inflammation and pain following eye surgery, such as cataract removal. It is also effective in managing inflammatory conditions of the eye, including uveitis and keratitis. The formulation is designed to provide rapid and sustained relief, reducing swelling, redness, and discomfort. Additionally, it is often prescribed post-operatively to prevent complications and promote healing. Its strong anti-inflammatory properties make it a reliable option for severe ocular inflammation cases.