3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione

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Reagent Code: #217430
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CAS Number 827026-45-9

science Other reagents with same CAS 827026-45-9

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 289.25 g/mol
Formula C₁₃H₁₁N₃O₅
inventory_2 Storage & Handling
Storage  2-8°C

description Product Description

Used in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure, a derivative of thalidomide-like compounds, enables selective binding to cereblon, facilitating the degradation of disease-related proteins. This makes it valuable in developing treatments for cancers such as multiple myeloma and other hematologic malignancies. Also explored in the design of PROTACs (proteolysis-targeting chimeras) for enhanced specificity and potency in drug development. Additionally, it exhibits potential immunomodulatory and anti-angiogenic properties similar to thalidomide, supporting research in anti-inflammatory applications for chronic diseases.

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Size Availability Unit Price Quantity
inventory 500mg
10-20 days ฿760.00
inventory 1g
10-20 days ฿960.00
inventory 5g
10-20 days ฿3,860.00
inventory 25g
10-20 days ฿17,600.00
inventory 100g
10-20 days ฿56,000.00

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3-(4-Nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
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Used in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure, a derivative of thalidomide-like compounds, enables selective binding to cereblon, facilitating the degradation of disease-related proteins. This makes it valuable in developing treatments for cancers such as multiple myeloma and other hematologic malignancies. Also explored in the design of PROTACs (proteolysis-targeting chimeras) for enhanced s

Used in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its structure, a derivative of thalidomide-like compounds, enables selective binding to cereblon, facilitating the degradation of disease-related proteins. This makes it valuable in developing treatments for cancers such as multiple myeloma and other hematologic malignancies. Also explored in the design of PROTACs (proteolysis-targeting chimeras) for enhanced specificity and potency in drug development. Additionally, it exhibits potential immunomodulatory and anti-angiogenic properties similar to thalidomide, supporting research in anti-inflammatory applications for chronic diseases.

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